Distinct functions of synaptotagmin-1 and -7 in neurotransmitter release
Sina Zobel, Boris Bouazza-Arostegui, Thorsten Trimbuch, Christian Rosenmund · FENS Forum 2024
Besides its role in triggering fast neurotransmitter release, the protein Synaptotagmin-1 (Syt1) is also involved in the docking and priming process of synaptic vesicles (SVs) to the presynaptic active zone. Research indicates that Synaptotagmin-7 (Syt7) shares some functions with Syt1, but the specific mechanisms by which Syt7 exerts these functions are not well understood. To investigate the putative redundant role of Syt1/Syt7 in SV docking and priming we performed various experiments as high-pressure freezing and electron microscopy on hippocampal cultures, and electrophysiological recordi
ePoster · Neuroscience