Oxytocin as a novel therapeutic target to reduce neuroinflammation and protect brain development following pediatric traumatic brain injury
Marit Knoop, Marie-Laure Possovre, Ece Trak, Kelly Ceyzériat, Yohan Van de Looij, Alice Jacquens, Olivier Baud · FENS Forum 2024
Traumatic brain injury (TBI) is the leading cause of death in the pediatric stage, with detrimental consequences including psychosocial issues, cognitive deficits and motor abnormalities. In addition to the primary TBI impact, the subsequent neuroinflammatory response can become a contributing and even leading factor to the harmful effect of pediatric TBI on the brain. As such, finding ways to stabilize the reactive microglial phenotype is a key objective for TBI treatment. One potential factor is the neuropeptide oxytocin. Oxytocin has shown to be neuroprotective in adult neuroinflammatory st
ePoster · Neuroscience