Topic: C57bl6J mice

There is an active interest in torpor-like states for translational applications and the neural basis of torpor is presently a hot topic of research. Activation of Esr1-expressing preoptic area neurons generates torpor-like states, suggesting a link between hormonal status and torpor. This is an important consideration for the fundamental biology as well as translational applications, as gonadal hormones fluctuate greatly between, and within, individuals. The aim of the present study was to investigate the roles of sex and oestrus cycle / oestradiol (E2) in modulating mouse torpor tested acros