Topic: CA1 area

Navigating space to retrieve uncued rewards at remembered locations depends on intact hippocampal function. Indeed, learning novel reward locations in familiar environments requires synaptic plasticity and lasting reorganization of spatial representations in the CA1 area of the dorsal hippocampus. Such reorganization is absent when learning associations between rewards and non-spatial cues, for which spatial memory is not involved. Thus, the rodent brain selectively adjusts weights of hippocampal inputs, plasticity processes, and the stability of spatial representations, supporting adaptive be