TRESK potassium channel exerts a brake on neuronal excitability and modulates hippocampal synaptic plasticity
Helena Lluís Sánchez-Lafuente, Marija Radosevic, Aida Castellanos, Júlia Llimós-aubach, Gerard Callejo, Núria Comes, Corette J Wierenga, Xavier Gasull · FENS Forum 2024
To comprehend the brain’s dynamic physiology, we must understand the mechanisms underlying neuronal excitability, crucial for neurons’ electrical activation during synaptic communication. Of particular interest is controlled potassium current leakage via two-pore domain potassium channels which finely modulate the intrinsic excitability of neurons. TRESK, the latest discovered channel of the K2P family, has a well-characterized pivotal role in nociception. Intriguingly, it also exhibits widespread expression throughout central nervous system, yet its function within the brain has remained unex
ePoster · Neuroscience