Links between novelty, c-Fos expression, and hippocampal calcium activity in mice
Olga Rogozhnikova, Nikita Dokukin, Anna Ivanova, Olga Ivashkina, Victor Plusnin, Nikita Saveliev, Vladimir Sotskov, Ksenia Toropova, Konstantin Anokhin · FENS Forum 2024
The ability of organism to detect and respond to novelty is critical to adaptation in a changing environment. Here we studied how brain activity changes as environmental novelty decreases. To this end, we placed mice in an open field (OF) to explore it in four daily sessions and showed a significant decrease in exploration from days 1 to 4. We then analyzed the brain activity by imaging c-Fos expression after mice explored the OF once (high novelty) or four times (low novelty) and found that the decrease in novelty was accompanied by a decrease in cortical (prefrontal, retrosplenial, and somat
ePoster · Neuroscience