Excitatory and inhibitory synapses show a tight subcellular correlation that weakens over development
Sally Horton, Vincenzo Mastrolia, Rachel Jackson, Sarah Kemlo, Pedro Machado, M Alejandra Carbajal, Robert Hindges, Roland A Fleck, Paulo Aguiar, Guilherme Neves, Juan Burrone · FENS Forum 2024
Neurons receive correlated levels of excitation and inhibition, a feature that is important for proper brain function. In fact, a dysregulation in the balance between excitation and inhibition has been linked to many neurodevelopmental disorders, including autism, schizophrenia, and epilepsy. However, how this relationship between excitatory and inhibitory inputs is established during the dynamic period of circuit wiring remains unexplored. Using multiple techniques, including in utero electroporation, electron microscopy and electrophysiology, we reveal a tight correlation in the distribution
ePoster · Neuroscience