Topic: CA1 hippocampal pyramidal cells

Cortical principal neurons receive multiple synaptic inputs via their dendrites, integrate them in their soma and once a threshold is reached, generate action potentials. Dendritic branches express multiple mechanisms for modulation and integration of signals, depending on the spatiotemporal pattern of arriving inputs. Recently, we have reported a new structural feature of pyramidal neurons affecting neuronal signal processing: axon localization. In about 50% of CA1 hippocampal pyramidal cells, the axon emerges from a basal dendrite instead of the soma. Input to the axon-carrying dendrite (AcD