Topic: CA1 subfield

Declarative memories, comprising explicit knowledge of facts and experiences, are known to be dependent on the hippocampus. This study posited the CA1 subfield of the hippocampus as a pivotal neural locus for retrieving past experiences. We hypothesized that if the behaviour associated with these memories is not congruent with the current sensory information, it creates an internal conflict, potentially leading to a mixed-reality perception that suppresses the solely sensory or memory-driven behaviours. Employing the tet-tag system and optogenetics in transgenic mice, we activated memory ensem