Unveiling the influence of melanin on morphological and functional states of rat brain neurons in a rotenone-induced Parkinson's disease model
Margarit Danielyan, Michael Poghosyan, Anichka Hovsepyan, Vahagn Khachatryan, Kristina Nebogova, Kristine Karapetyan · FENS Forum 2024
Aims: Parkinson's disease (PD), a chronic neurological disorder affecting motor functions, is characterized by damage to dopaminergic neurons in the substantia nigra pars compacta (SNc). This study investigates the therapeutic properties of bacterial melanin (BM), known for enhancing brain trophic effects, inhibiting inflammation, and mitigating gliosis—a key aspect in PD development.Methods: To assess rat brain morpho-functional states, we conducted histochemical and morphometric studies on SNc cellular structures post-rotenone intoxication and under BM influence. Experiments involved intact
ePoster · Neuroscience