Topic: Ca2+ microdomains

Oligodendrocyte precursor cells (OPCs) serve as progenitors for oligodendrocytes (OLs) throughout their life, contributing to developmental and adaptive myelination, as well as myelin repair. OPCs are known to make synaptic and extra-synaptic contacts with axons, but the mechanisms by which they integrate the information relayed by the neuronal activity into Ca2+ signals, which in turn influence their fate and survival, are still unclear. Using newly developed transgenic mouse lines to express genetically encoded Ca2+ sensors in OPCs, we performed 2-photon microscopy in the somatosensory corte