Impaired hippocampal CA2 place cell responses to social odors in a rat model of Fragile X Syndrome
Emma Robson, Margaret Donahue, Alexandra Mably, Peyton Demetrovich, Laura Colgin · FENS Forum 2024
Hippocampal subregion CA2 has been implicated in social memory. CA2 contains spatially modulated “place cells” that change their firing patterns (“remap”) during social interactions (Alexander et al., 2016). Our preliminary results suggest that CA2 place cell remapping is driven by the olfactory content of social experiences. Fragile X Syndrome (FXS) is a neurodevelopmental disorder associated with abnormal social behaviors. To our knowledge, the activity of CA2 place cells during social interactions has not been examined in relation to FXS. Here, we recorded CA2 place cells in wildtype (WT) c
ePoster · Neuroscience