Topic: CA3 interneurons

Spatial navigation impairments are among the earliest clinical manifestations of Alzheimer’s Disease (AD). Pyramidal cells of the hippocampus fire selectively when the animal is in a specific location in the environment, leading to the theory that the hippocampus plays a crucial role in forming a cognitive map of the environment. The phenomenon of “remapping”, where specific cells exhibit selective firing in distinct environments, is thought to support the formation of different memories. By performing in-vivo electrophysiological recordings in freely moving mice while they navigate through di