Topic: Cadherin-22

The function of the cerebral cortex relies on the precise integration of diverse neuronal populations during development, which is regulated by dynamic fine-tuning mechanisms maintaining the balance between excitation and inhibition. For instance, the development of excitatory pyramidal cells is simultaneously and precisely counterbalanced by the formation of inhibitory synapses during the maturation of neuronal circuits. Although this process relies on neuronal activity, different types of pyramidal cells likely respond to changes in activity through the expression of cell-specific genes. How