Topic: cadmium (Cd)

Metal exposure is an intriguing potential culprit in the cause of sporadic amyotrophic lateral sclerosis (ALS). Lead (Pb), mercury (Hg), cadmium (Cd) and arsenic (As) are singled out among the ten chemicals of major public health concern by the World Health Organisation. There are numerous case reports and case-control studies linking those metals to an ALS phenotype. Additionally, some studies have demonstrated higher levels of these metals in the blood, cerebrospinal fluid, urine, or spinal cords of patients with ALS compared to controls. Recently, it has been proposed that the interaction b