Topic: CAG-hACE2 transgenic mice

The renin-angiotensin system (RAS) is expressed in the brain and impacts physiological several activities. Dysregulation of the RAS may be associated with a wide spectrum of brain diseases defined by severe neuroinflammation, oxidative stress, and age-related pathophysiological processes. The CAG-hACE2 transgenic mice were designed to express the human angiotensin-converting enzyme 2 (hACE2) receptor, which is involved in the RAS. However, the relevance of ACE2 at the brain level remains unclear. The purpose of our research is to characterize CAG-hACE2 transgenic mice of both sexes, females an