ePoster · Neuroscience
Investigation of the Mechanisms Regulating Postsynaptic Density
Nahid Safari, Christian Tetzlaff · Bernstein Conference 2024
Memory and learning are significantly influenced by long-term changes in synaptic strength, though the exact molecular mechanisms remain unclear. The postsynaptic density (PSD) is a critical component for storing and organizing synaptic long-term changes. The PSD itself is organized into complex nano-clusters, which are modulated during synaptic plasticity. However, the underlying organizational principles yielding such changes and maintaining stability otherwise are still to a large degree unknown. Recent research assumes that liquid-liquid phase separation (LLPS) might be crucial for PSD for