Topic: Cajal-Retzius (CR) cells

Cajal-Retzius (CR) cells are essential players in early brain development. In the first postnatal week (P0-P7), these glutamatergic cells densely populate the most superficial layer of the cerebral cortex, providing a transient source of excitatory inputs to immature pyramidal neurons. In the murine brain, CR cells are greatly reduced in the neocortex after postnatal week two, whereas in hippocampus, they persist throughout postnatal development and even into adulthood. During this time, they are integrated in the CA1 network, and recent work (Glærum et al. 2024) has showed that their persiste