Perinatal serotonin signalling dynamically influences the development of GABAergic circuits with consequences for lifelong sensory perception
Gabriel Ocana Santero, Hannah Warming, Veronica Munday, Caius Gibeily, Christopher Hemingway, Heather A. MacKay, Abhishek Saha, Fei Deng, Yulong Li, Adam M. Packer, Trevor Sharp, Simon J. B. Butt · FENS Forum 2024
Serotonin is a critical regulator of cortical neurodevelopment whose perturbation is associated with neurodevelopmental disorders. Here, we explore its neurodevelopmental dynamics and how they dictate the emergence of cortical population dynamics by combining longitudinal multiphoton imaging of serotonin and calcium sensors with slice electrophysiology in the somatosensory cortex of interneuron-labelled mice with a genetic (knock-out), or pharmacological (postnatal fluoxetine) developmental disruption of serotonin dynamics. We have characterised global and local cortical serotonergic fluctuati
ePoster · Neuroscience