Neurons repurpose the integrated stress response effector GADD34 to enhance protein synthesis in response to neuronal activity
Mauricio Oliveira, Muhaned Mohamed, Megan Elder, Keylin Banegas-Morales, Maggie Mamcarz, Emily Lu, Ela Golhan, Nishika Navrange, Snehajyoti Chatterjee, Ted Abel, Eric Klann · FENS Forum 2024
Neurons are highly plastic cells, altering the proteome to adapt to environmental cues. These changes are governed by fluctuations in protein synthesis pace and the nature of the mRNAs that are being translated. Although it is well established that de novo protein synthesis is fundamental to consolidate long-term memory, many details remain unknown, including the molecular mechanisms that trigger protein synthesis pace elevation that drive consolidation. Mounting evidence suggests that triggering long-term memory consolidation requires the release of the translation initiation brake, particula
ePoster · Neuroscience