Deconstruction of the role of CB1 receptor in CaMKII+ neurons in the context of obesity, metabolic syndrome, binge-eating, and food addiction
Inigo Ruiz de Azua, Elena Martin-Garcia, Laura Domingo-Rodriguez, Rafael Maldonado, Beat Lutz · FENS Forum 2024
AIMS: The activation of CB1 receptor (CB1R) is reported to favor energy accumulation and promote resiliency against stress. The aim of this study is to elucidate whether CB1R expression in CaMKII+ neurons is sufficient to restore its role in the regulation of energy metabolism and contingent behaviors.METHODS: To this end, we applied a genetic strategy to reconstitute CB1R expression at endogenous levels in CaMKII+ neurons (CaMKII-CB1-RS).RESULTS: The rescue of CB1R expression in these neurons promotes feeding behavior causing fasting-induced hyperphagia, increased motivation and impulsivity t
ePoster · Neuroscience