Modulation of CaV1.2 currents tunes dendritic growth in cultured hippocampal neurons
Stefano Lanzetti, Pietro Mesirca, Alessandra Folci, Rosina Maier, Eleonora Torre, Sabrin Haddad, Cornelia Ablinger, Gerald. J. Obermair, Marta Campiglio, Matteo E. Mangoni, Valentina Di Biase · FENS Forum 2024
L-type voltage-gated calcium channels (L-VGCCs) are upstream of competing pathways that promote or inhibit dendritic growth. How L-VGCCs achieve signaling specificity remains unknown. We hypothesize that modulation of ICaL determines distinct processes controlling dendritic growth. To address this issue fluorescence imaging experiments were conducted on young murine cultured hippocampal neurons. Our findings show that dihydropyridine (DHP) blockers suppress dendritic growth and overexpression of DHP-insensitive CaV1.2 mutant prevented this effect, indicating that CaV1.2 is the channel isoform
ePoster · Neuroscience