Structural determinants of dopamine receptor agonist selectivity
Olga Trovato, Julia Baumann, Mitja Amon Posch, Moritz Henninger, Sarah Seidel, Ana Lechuga, Leandra Abt, Michiel Langeslag, Marita Bauer, Germana Thaler, Teresa Kaserer, Andreas Lieb · FENS Forum 2024
Dopamine receptors (DRs) are G protein-coupled receptors (GPCRs) expressed in the central nervous system. When activated, DRs can trigger different downstream signal transduction cascades based on which they are divided into two major classes: D1-like, which includes excitatory D1 and D5 receptors, and D2-like, including inhibitory D2, D3 and D4 receptors. Drugs acting on DRs are used to treat several neurological disorders, like Parkinson´s disease (PD), schizophrenia, depression or bipolar disorders. PD, for example, is caused by the early death of dopaminergic neurons in substantia nigra pa
ePoster · Neuroscience