Non-canonical adrenergic neuromodulation of motoneuron intrinsic excitability through β-receptors in wild-type and SOD1 (G93A) mice
Guillaume Caron, Stefano Antonucci, Natalie Dikwella, Sruthi Sankari Krishnamurthy, Anthony Harster, Hina Zarrin, Aboud Tahanis, Florian olde Heuvel, Simon M. Danner, Albert C. Ludolph, Kamil Grycz, Marcin Baczyk, Daniel Zytnicki, Francesco Roselli · FENS Forum 2024
Altered neuronal excitability and synaptic inputs to motoneurons are part of the pathophysiology of Amyotrophic Lateral Sclerosis. The cAMP/PKA pathway regulates both of them but therapeutic interventions at this level are limited by the lack of knowledge about suitable pharmacological entry points. Here we used transcriptomics on microdissected and in situ motoneurons to reveal the modulation of PKA-coupled receptorome in SOD1(G93A) ALS mice, vs WT, demonstrating the dysregulation of multiple PKA-coupled GPCR, in particular on vulnerable MN, and the relative sparing of β-adrenergic. In vivo M
ePoster · Neuroscience