Genetic deletion of astrocytic calcineurin B1 prevents cognitive impairment and neuropathology development in acute and chronic mouse models of Alzheimer’s disease
Giulia Dematteis, Laura Tapella, Gianluigi Forloni, Armando Genazzani, Claudia Balducci, Dmitry Lim · FENS Forum 2024
Alzheimer’s disease (AD) represents an urgent yet unmet challenge for modern society, calling for exploration of innovative targets and therapeutic approaches. Astrocytes, considering their crucial functions in the CNS, represent promising cell-target.Our aim was to investigate if deletion of the regulatory CaNB1 subunit of calcineurin in astrocytes could mitigate AD-related memory deficits, neuropathology and neuroinflammation.We have generated two, acute and chronic, AD mouse models with astrocytic CaNB1 deletion (ACN-KO). In the acute one we evaluated the ability of β-amyloid oligomers (AβO
ePoster · Neuroscience