CB1R activation decreases NMDA-induced neurotoxicity in APPSw/Ind mice model of AD
Gemma Navarro Brugal, Iu Raïch, Joan Biel Rebassa, Jaume Lillo, Catalina Pérez-Olives, Toni Capó, Irene Reyes-Resina, Rafael Franco · FENS Forum 2024
Background: Nowadays, Alzheimer's Disease is the type of dementia with the highest incidence worldwide. NMDA receptor is one of the key players in this pathology, causing neurotoxicity and neuronal death after excessive stimulation. On the other hand, the cannabinoid receptor CB1 induces a neuroprotective role. In this research we aim to analyze the capacity of the CB1R to regulate and reduce NMDAR overstimulation in Alzheimer's pathology.Results: It has been demonstrated that CB1R and NMDAR colocalize and form heteromeric complexes in transfected HEK-293T cells. In the same cells, NMDAR activ
ePoster · Neuroscience