Topic: canonical microcircuits

To understand how the brain is wired calls for investigating how the brain's wiring information (the connectome) is encoded in the genome. From small insects to humans, the apparent complexity of biological neural networks, in particular the information amount required to describe all connections in the connectome, far exceeds the genomic storage capacity. To explain the discrepancy in information volume between a direct description of the brain network and the coding genome's size, an emerging hypothesis, coined the genomic bottleneck principle, proposes that the wiring information must be co