Topic: cardiac interoception

Interoception, the process through which afferent information reaches the brain to report the body's physiological state, is a critical element in adapting responses to potential threats. Cardiac interoceptive information has been shown to play a crucial role in these adaptive defensive processes. Neuronal circuits within the periaqueductal grey (PAG) play a pivotal role in controlling heart function, yet it remains unknown how PAG circuits process interoceptive signals as part of a defensive reaction to threats. Employing trans-synaptic retrograde tracing, we demonstrate that glycinergic neur