Loss of microglial MCT4 leads to defective synaptic pruning and anxiety-like behavior in mice
Katia Monsorno, Kyllian Ginggen, Andranik Ivanov, An Buckinx, Arnaud L. Lalive, Anna Tchenio, Sam Benson, Marc Vendrell, Angelo D’Alessandro, Dieter Beule, Luc Pellerin, Manuel Mameli, Rosa Chiara Paolicelli · FENS Forum 2024
Microglia, the tissue-resident macrophages of the central nervous system, actively participate in brain development by supporting neuronal maturation and refining synaptic connections. These cells are emerging as highly metabolically flexible, able to oxidize a variety of nutrients to meet their energy demand. Accumulating evidence points towards the involvement of metabolism and differential substrates catabolism in the regulation of immune cells. Lactate, which is abundant in the brain and sustains synaptic activity, also dictates responses of peripheral immune cells. However, the physiologi
ePoster · Neuroscience