Chemogenetic modulation of parvalbumin interneurons in the medial prefrontal cortex: Relevance to cognitive schizophrenia-like symptoms in rats
Jan Svoboda, Martin Vodička, Dominika Radostová, Daniela Kunčická, Karolína Hrůzová, Daniela Černotová, Aleš Stuchlík · FENS Forum 2024
The balance between excitatory and inhibitory systems is crucial for the normal functioning of the brain, and dysfunction in the inhibitory system may be a potential mechanism for psychosis. Current studies emphasize parvalbumin-positive (PV+) GABAergic interneurons as a key component in the development of schizophrenia symptoms, with reduced PV protein levels found in cortical PV+ interneurons in individuals with schizophrenia. Rodent models of schizophrenia indicate that the medial prefrontal cortex (mPFC) is the main structure where PV neurons exhibit aberrant function. However, it is still
ePoster · Neuroscience