Single-nucleus and spatial transcriptomic profiling of human temporal cortex and associated white matter reveals novel AD trait associations
Pallavi Gaur, Julien Bryois, Daniela Calini, Lynette Foo, Jeroen J M Hoozemans, Dheeraj Malhotra, Vilas Menon · FENS Forum 2024
Alzheimer’s disease (AD) is a neurodegenerative disorder with complex pathological manifestations and is the leading cause of cognitive decline and dementia in elderly individuals. A major goal in AD research is to identify new therapeutic pathways by studying the molecular and cellular changes in the disease, either downstream or upstream of the pathological hallmarks. In this study, we present a comprehensive investigation of cellular heterogeneity from temporal cortex region of 40 individuals, comprising healthy donors and individuals with differing tau and amyloid burden. Using single-nucl
ePoster · Neuroscience