Unravelling the neuroprotective role of mitochondrial quality control in LUHMES, a dopaminergic model of Parkinson’s disease
Marta Dominguez-Prieto, Yulli Passos, Nicoleta Moisoi · FENS Forum 2024
Lund Human Mesencephalic (LUHMES) cells are a cellular model of Parkinson’s disease (PD) that can be grown as undifferentiated cells and be differentiated into dopaminergic neurons. Here we have identified a series of changes in mitochondrial phenotypes that occur throughout the differentiation process and need to be considered when using this model in a PD context. Besides the acquisition of a neuronal dopaminergic phenotype with increased levels of tyrosine hydroxylase, dopamine receptor D2 or β-III-tubulin, we identified changes in mitochondrial markers reflecting an important reduction in
ePoster · Neuroscience