Topic: caspase 3

During Cerebral ischemia/reperfusion injury (I/RI), NMDA receptor activity increases, leading to an excessive entry of sodium and calcium, which damages neurons. Therefore, deletion of NMDA receptor subunits may reduce cell death induced by acute brain injury. MK801 is a non-competitive NMDA receptor antagonist that can block NMDA ion channels. In this experimental study, Wistar rats were divided into 6 groups:Sham, I/R, I/R+NMDA (0.5 mg/kg, IV), I/R+MK801 (0.5 mg/kg, IV), I/R+NMDA+ electrophysiology, and I/R+MK801+ electrophysiology. The acute cerebral ischemic injury was induced in rats by o

Spinal cord injury (SCI) results from direct damage to the spinal cord, devastating patients’ quality of life and emotional and economic stability. Unfortunately, fully effective therapeutic strategies have yet to be developed to treat this disease, affecting millions worldwide. Apoptosis and autophagy are critical cell death signaling pathways after SCI that should be targeted for early therapeutic interventions to mitigate their adverse effects and promote functional recovery. Tibolone (TIB) is a selective tissue estrogen activity regulator (STEAR) with neuroprotective properties demonstrate