Levels of serotonin during brain development important for the functional interplay of instructing transmitter systems
Marta Samina, Thibault Merkelijn, Sabrina Hanswijk, Lidiane Garcia, Josefine Witteveen, Sara Migliarini, Massimo Pasqualetti, Judith Homberg, Sharon Kolk · FENS Forum 2024
The prefrontal cortex (PFC) is responsible for higher cognitive tasks, and its ‘malfunction’ is shared across serotonin (5-HT)-related neuropsychiatric disorders and often find its origins during development. Proper cortical development is directed by a sequence of intrinsic ( transcription factors, local placental-derived 5-HT) and extrinsic (instructing 5-HT and catecholaminergic afferents) events. Recently, our group has shown a functional interplay between the 5-HT and catecholaminergic prefrontal projection systems during development leading to a distortion in PFC cytoarchitecture. Lack o
ePoster · Neuroscience