Network modulation using pathway and neuromodulator specific chemogenetics in macaque frontal cortex: Foraging behaviour, imaging and histology
Clémence Gandaux, Jérôme Sallet, Emmanuel Procyk, Charles Wilson · FENS Forum 2024
A critical advance in neuroscience is the ability to intervene reversibly in a pathway-specific manner on interactions between brain regions, providing understanding of the causal role of those interactions, but also moving us towards targeted therapies for pathologies linked to neural pathways. We present data on pathway-specific DREADDs (Designer Receptor Exclusively Activated by Designer Drugs) in macaque monkeys. This approach is only now emerging for primates, and permits the targeted modulation of a specific neural pathway over a period of hours. We conducted two DREADD experiments to sp
ePoster · Neuroscience