Effects of anti-LGI1 human monoclonal antibodies on mouse behavior, ultrastructure, and ion channel distribution at synapses and axon initial segments
Jacqueline Montanaro, Hana Stefanickova, Mary Muhia, Christian Geis, Claudia Sommer, Josefine Sell, Hans-Christian Kornau, Harald Prüß, Ryuichi Shigemoto · FENS Forum 2024
Leucine-rich glioma inactivated 1 (LGI1) is a soluble secreted protein which links Adam22/23 proteins across the synaptic cleft and is also abundant in the axon initial segments of in the hippocampus. Anti-LGI1 autoantibodies have been found in CSF and serum of acquired epilepsy patients with symptoms of limbic encephalitis with amnesia and seizures. Previous studies showed human LGI1 autoantibodies co-precipitated with voltage-gated (VG) potassium channel complexes in rodent tissue. As VG-ion channels help maintain homeostasis in hippocampal action potentials, dysregulation of these channels
ePoster · Neuroscience