Topic: CaV2.3

Voltage-gated calcium channels (Cav) mediate calcium influx in living cells and are necessary for essential physiological functions such as muscle contraction and excitation-transcription coupling. Channels of the Cav2 family (Cav2.1, 2.2, and 2.3) are highly expressed in the central nervous system (CNS) and are important regulators of neuronal excitability. They are involved in pre- and postsynaptic functions where they, for example, trigger neurotransmitter release. Cav2.3 (α1E) is involved in neuronal development and, when compared to other α1 subunits, shows the strongest expression in mou