Unveiling microvascular occlusions in traumatic brain injury: Insights into blood-brain barrier permeability using super-bright nanoparticles
Atonia Clarissa Wehn, Martina Fetting, Andrey Klymchenko, Nikolaus Plesnila, Igor Khalin · FENS Forum 2024
Traumatic brain injury (TBI) manifests with reduced cerebral blood flow and heightened blood-brain-barrier (BBB) permeability, yet the underlying mechanisms remain elusive. This study explores the involvement of microvascular occlusions (mVOs) in the traumatic penumbra and their contribution to these processes. mVOs were visualized in C57BL/6 mice by systemic administration of super-bright 30 nm lipidic nanodroplets (LnDs) one hour following controlled cortical impact TBI. Brains were investigated by fluorescent confocal imaging and correlative light-electron microscopy (CLEM). Additionally, c
ePoster · Neuroscience