Topic: CB1

Autism spectrum disorder is characterized by a wide range of symptoms, including impairments in social interactions, communication, and emotion-related behavior. In this study we aimed to uncover the changes of inhibitory basket cell outputs in the prefrontal cortex and basolateral amygdala, regions that play a central role in the expression of core symptoms in autistic behaviors.We observed that valproate treatment at E12.5 resulted in a decrease in ultrasound vocalizations in the pups (n=12) and an increase in tactile sensitivity assessed by the von Frey test in comparison to controls (n=13)