The expression and functionality of CB1R-NMDAR complexes are decreased in Parkinson’s disease models
Irene Reyes-Resina, Jaume Lillo, Iu Raïch, Joan Biel Rebassa, Ana Muñoz, José Luis Labandeira-García, Rafael Franco, Gemma Navarro · FENS Forum 2024
Parkinson’s disease (PD) is the second most common neurodegenerative disorder worldwide. One of the hallmarks of PD is the alteration in the expression and function of NMDA receptor (NMDAR) and cannabinoid receptor 1 (CB1R). The presence of CB1R-NMDAR complexes has been described in neuronal primary cultures, where the activation of CB1R was suggested to counteract the detrimental NMDAR overactivation in an AD mice model. Thus, we aimed to explore the role of this receptor complex in PD. By using BRET assay, it was demonstrated that a-synuclein induces a reorganization of CB1R-NMDAR complex in
ePoster · Neuroscience