Medial prefrontal cortical Cerebellin-4 modulates synapses critical for long-term memory
Louise Goh, Jai Polepalli · FENS Forum 2024
Neuropsychiatric disorders present a complex array of behavioral symptoms, often encompassing deficits in learning and memory. However, our comprehension of the synaptic and circuitry abnormalities underpinning these conditions remains somewhat constrained. Many of these disorders share genetic anomalies involving synaptic cell adhesion molecules, including neurexins (Nrxns), and their interactors, cerebellins (Cbln1-4), which have been implicated in synapse formation and plasticity. Of particular interest, Cbln4 is enriched in brain regions associated with the memory process, such as the pref
ePoster · Neuroscience