Subpopulations of hippocampal inhibitory interneurons contribute differently to engram formation in APP/PS1 mice
William Fernandes Paes de Barros, Miguel De Castro Vera Cruz Vieira, Shimon Jude Swer, Camin Dean, Silvia Viana da Silva, Matthias Haberl · FENS Forum 2024
Understanding the neural mechanisms underlying memory formation and retrieval is fundamental to unraveling the pathophysiology of Alzheimer's disease (AD). Inhibitory interneurons have fundamental roles in shaping neural circuits and synaptic plasticity within the hippocampus, a brain region critical for memory encoding and consolidation. However, the specific contribution of inhibitory interneurons to the formation and maintenance of engrams, the neural representations of memories, remains poorly understood, particularly in the context of AD.To determine neurons participating in the engram fo
ePoster · Neuroscience