Topic: CD36

Obesity is a major risk factor for metabolic and neuropsychiatric disorders. High-fat diets have been shown to trigger systemic and central inflammation, particularly in the hypothalamus. The lingual CD36 receptor plays a crucial role in oro-gustatory perception and is downregulated in individuals with obesity. NKS-3, a non-caloric high affinity CD36 agonist, exerts systemic anti-inflammatory effects by reducing pro-inflammatory cytokines; however, its potential impact on neuroinflammation is not known. C57BL/6 male mice were fed with either a high-fat (HFD) or a standard (STD) diet for 12 wee