Progesterone alleviates neurological deficit and striatal ectonucleotidase activities after cerebral hypoperfusion in rats
Katarina Bobic, Ivana Gusevac Stojanovic, Ana Todorovic, Jelena Martinovic, Jadranka Miletic Vukajlovic, Snezana Pejic, Dunja Drakulic · FENS Forum 2024
Progesterone (P4) has shown promising results in diminishing the effects of cerebral hypoperfusion (CH) in prefrontal cortex. Therefore, our goal was to further analyze the neuroprotective mechanism of P4 in adult Wistar rats following bilateral occlusion of common carotid arteries (2VO). We investigated its impact on neurological function and activity of striatal extracellular purine metabolizing enzymes, CD39 and CD73. Following either sham or 2VO operation, for 7 consecutive days, animals (n=12) received s.c. treatments of commercial flax oil (V, 1 mg/kg) (Sham+V and 2VO+V groups) or 1.7 mg