Targeting the T-cell response as a novel therapeutic strategy for Parkinson's disease
Federica Maria Conedera, Hans Rudolf Widmer, Volker Enzmann, Jens Volker Stein · FENS Forum 2024
Parkinson's disease (PD) is characterized by the loss of dopamine-producing neurons and abnormal alpha-synuclein buildup, leading to motor and cognitive symptoms. CD4+ T-cells play a crucial role in PD, influencing disease progression differently across preclinical models. While they aid zebrafish regeneration, they hinder brain recovery in mice. In humans, CD8+ T-cells increase more significantly than CD4+ in PD cases, and their infiltration precedes alpha-synuclein aggregation and neuronal death, suggesting their relevance in disease onset.Here, we set out to uncover which T-cell subsets reg
ePoster · Neuroscience