Unveiling the role of microglia in synaptic pruning in multiple sclerosis
Catarina Barros, Ainhoa Alberro, Adelaide Fernandes · FENS Forum 2024
Microglia are keen responders in numerous neurodevelopmental and neurodegenerative conditions, including in Multiple Sclerosis (MS). While previous studies hinted about microglia involvement in synaptic elimination, their correlation with the appearance of cognitive deficits in MS remains unclear. Here, we focused on understanding the impact of microglia in MS synapse pruning in the cognitive-related region, the hippocampus, using postmortem tissue of MS patients. Hippocampal samples were obtained from the Netherlands Brain Bank, including non-demented control (NDC) and MS donors that were mat
ePoster · Neuroscience