Topic: Cdh2

During embryonic development, neural stem cells, known as radial glial cells (RGCs), give rise to the different subtypes of excitatory neurons and macroglia cells that form the mature neocortex. Precisely regulated mechanisms are crucial for the proper development of this structure, from the generation of neural cells to their correct migration and establishment of specific connections. Among the many genes described to regulate its proper development, cell-cell adhesion molecules such as Cdh2 or its associated protein Afadin play important roles. Inactivation of these genes in the dorsal tele