Topic: cell adhesion

The C-terminal binding protein 1 (CtBP1) is a ubiquitously expressed, dual-function protein. In the nucleus, it nucleates corepressor complexes that control chromatin-modification and gene expression. In the cytoplasm, it regulates membrane trafficking processes by controlling the membrane fission reaction. Our previous study revealed an involvement of CtBP1 in the control of neural activity‐regulated genes such as BDNF, Arc and Fos in the mature brain. Recently, individuals with a missense mutation in CTBP1 have been reported to have intellectual disability and neurodevelopmental problems. Th

It is well-established that neurodegenerative diseases lead to structural and functional reconfigurations in neural networks. However, it is less clear how altered network dynamics contribute to increased vulnerability of specific neuronal populations to disease onset and spread. Here, we aimed to identify how ALS pathology affects the structural and functional dynamics of motor neuron networks, and the underlying biological pathways that contribute to cause such dysfunction. Multielectrode arrays (MEAs) enable longitudinal assessment of electrophysiological activity in vitro, thus facilitatin