Upregulation of Negr1 converges into core impaired processes in autism spectrum disorders
Mariam Marie Chellali, Amos Fumagalli, Olga Shevtsova, Ilias Ziogas, Giulia Colombo, Giovanni Morelli, Andrea Barberis, Francesca Porceddu, Angelo Reggiani, Alessandro Gozzi, Yuri Bozzi, Giovanni Piccoli, Laura Cancedda · FENS Forum 2024
Diverse neurodevelopmental syndromes (e.g. Fragile X) are caused by alterations in specific genes leading to pervasive impairments comorbid with autism (i.e. social and repetitive behaviors). Although all ASDs converge into common core behaviors, genetic variants in ASD are very heterogeneous. Here, we describe a cleavable cell adhesion molecule (Negr1) as upregulated in the brain of 5 diverse mouse models of ASDs (including Fragile X) and postmortem brains from people with autism or Fragile X, and causative of core ASD behaviors and brain alterations when up-regulated in wild-type (WT) animal
ePoster · Neuroscience