Unraveling mouse striatal development from embryonic to postnatal stages
Olga Varea, Jordi Abante, Cristina Vila, Cinta Gomis, Inés Castañeda, Mohammad Usman, Sara Palma, Sophie V. Rowlands, Daniel Ortiz, Zaal Kokaia, Anne E. Rosser, Petia I. Radeva, Josep M. Canals · FENS Forum 2024
The embryonic striatal development is a complex orchestrated process driven by a pattern of gene expression at neuronal progenitors. The correct maturation of striatal projection neurons (SPNs) that populate the striatum depends on their coordinated differentiation and their posterior organization into the striatal cytoarchitecture. Single-cell analysis can shed light into the physiology and pathology of striatal development, currently hampered by the heterogeneity of neural progenitors and the lack of gene markers. Here, we define for the first time the differentiation trajectories of SPNs by
ePoster · Neuroscience